performed mortuary practices analyses. TV Actress. Showcase your skills and bolster your data science credentials. What is a Scatterplot in Data Visualization, Machine Learning in R: Building a Classification Model. Modern humans have populated Europe for more than 45,000 years1,2. Furthermore, we examined whether the patient's age, the etiology of their hearing loss, the depth of the electrode insertion, and a slow electrode insertion affect the result of postoperative speech audiometry (PSA). Sikora, M. et al. Sikora, M. et al. - Technical researcher and data analyst under the supervision of Dr. A. Meyer and Dr. S. Bae at UCLA. Kozowski, S. K., Potowicz-Bobak, M., Bobak, D. & Terberger, T. New information from Maszycka Cave and the Late Glacial recolonisation of Central Europe. Initial Upper Palaeolithic humans in Europe had recent Neanderthal ancestry. Jensen, T. Z. T. et al. Within the pipeline, the adapters were removed by AdapterRemoval 2.2.065, reads were mapped with BWA 0.7.12 aln/samse algorithm66, duplications were removed by DeDup 0.12.1 (https://github.com/apeltzer/DeDup) and damage patterns of each library were checked with mapDamage 2.0.6 and 2.0.967. Samples with a percentage of human DNA in shotgun data around 0.1% or greater were enriched for a set of 1,237,207 targeted SNPs (1240k capture) across the human genome6. Feldman, M. et al. I have an undergraduate degree in . Learn in-demand skills with a structured course that prepares you for the world of data science as it is today. Amina is a software engineer, who is also an accessibility advocate and content creator. assembled archaeological material, descriptions and interpretations. We also compared its affinity to El Mirn (northern Spain), the oldest Magdalenian-associated individual sequenced to date (19ka). Genetics 203, 881891 (2016). Earlier I had practiced a bit of MySQL, but here through this course I got introduced to PostgreSQL. I came across her YouTube through Ken Jee. Lcuyer, C., Hillaire-Marcel, C., Burke, A., Julien, M. A. Second, the ancestry of individuals associated with the Epigravettian culture (Villabruna cluster), which was found to genetically connect European and Near Eastern hunter-gatherers, reached southern Europe well before the transition between the Early and Late Epigravettian4,15 and possibly as early as the GravettianEpigravettian transition. "Presumably, these people came from the Balkans, arrived first in northern Italy around the time of the glacial maximum and spread all the way south to Sicily.". Product development is, by far, my favorite data science use case for two main reasons. It was awesome seeing the thought process behind each of the questions - it helps students immensely! Patterson, N., Price, A. L. & Reich, D. Population structure and eigenanalysis. Join now Sign in . Dismiss. Tina_Huang_Resume_i.pdf - Tina Huang hellotinah@gmail.com Limits of long-term selection against Neandertal introgression. . It can take several minutes for a query to complete, and if youre using a lot of data the whole table may be locked up. & Banks, W. E. in Les Socits Gravettiennes du Nord-Ouest Europen: Nouveaux Sites, Nouvelles Donnes, Nouvelles Lectures (eds Touz, O., Goutas, N., Salomon, H. & Noiret, P.) 323266 (Presses Univ. 1.Introduction. Int. Sci. This was achieved through collaboration with local curators and scientists from the countries where the skeletal material is preserved and who are listed among the authors of this study. Bioinformatics 29, 16821684 (2013). Sci. & Fennema, K. Hunters of the Golden Age: The Mid Upper Palaeolithic of Eurasia, 30,000-20,000 bp (Univ. . What is Connection Map in Data Visualization? Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Meyer, M. & Kircher, M. Illumina sequencing library preparation for highly multiplexed target capture and sequencing. Happy International Womens Day! Shes the author of the popular Data Science: The Complete Guide and the creator of the popular Data Science Cookbook. She was also one of the founders of the Stanford Data Science Society. A user manual including an installation guide is available at https://haproh.readthedocs.io/en/latest/hapROH_with_contamination.html. Synergy of Ag and AgBr in a Pressurized Flow Reactor for Selective 2, 17561762 (2007). Int. The phylogenetic reconstruction of Epigravettian-associated genomes, with Pradis 1 diverging more deeply than all others, indicates that the turnover took place much earlier than 17kathe date of the more derived Tagliente 2 genome. a, MDS plot of pre-LGM individuals. Soonafter8 ka, Sidelkino ancestry was absent in eastern Spain but it had already reached northern Iberia alongside an increase in Oberkassel ancestry (Fig. Along with pushing for more accessibility, she also creates content around working in the tech industry, the challenges that come with it, and career advice. Fab Business Solutionsis a ProfessionalNewsPlatform. You need more data until you have the right ingredients to make a good recipe, but you also need less data until you have the right amount of ingredients to make a bad recipe. The Magdalenian culture was widely distributed in southwestern, western and central Europe after the LGM33. Curr. Details on individuals involved in the analysis, read counts processing and allele frequency computation are provided in the Supplementary Information, section12 and Supplementary Data 1.J and 3.G. 35, 15471549 (2018). As she gains working experience with one of the FAANG companies, Tina continues to share interesting details about her career journey with the audience. View Tina Zhang's business profile as Brand Specialist at Dymind Biotechnology. TV Actress. The sequence alignment/map format and SAMtools. Courses hellotinah "The data we gained from this study provides us with astonishingly detailed insights into the developments and encounters of West Eurasian hunter-gatherer groups," Posth summarises. 2022-112-4f84b - Ecologizr - Chapter 2 Science Education in Algeria 13, 24472461 (2018). Lifetime access to all course materials and updates. The Gravettian from a palaeodemographic point of view. Become the most confident candidate in the room. We further validated the genetic distinction between the Vstonice and Fournol clusters observed in the MDS plot with a series of f4-statistics (Supplementary Data 2.B). Last Name Huang #8. Extended Data Fig. What is a Pie Chart in Data Visualization? A dynastic elite in monumental Neolithic society. Overall, the Solutrean-associated Le Piage II individual links the preceding Fournol ancestry with the succeeding ancestry found in El Mirn, providing direct evidence for genetic continuity throughout the LGM in southwestern and western Europe. 2b). Second, data-driven product development meshes very well with my own philosophy, commonly known as the 80/20 rule, where 80% of the results come from just about 20% of inputs. Extended Data Fig. c, Admixture graph modelling of the main pre-LGM European hunter-gatherer lineages created using qpGraph. Genomic data have shown that modern humans were present in western Eurasia1,2 at least 45ka. You are using a browser version with limited support for CSS. This may have prompted people from the south to expand their habitat. For ds_halfUDG libraries, we masked 2bp from both ends of the reads with trimBam in bamUtil 1.0.13 (https://github.com/statgen/bamUtil) to remove the damaged sites. 7,794 followers. This website is about taking one step at a time to ultimately live more fulfilling lives. In this episode we go through a couple really superb resumes that you should model yours after. We applied ANGSD 0.93470 and hapCon71 for libraries from male individuals, and applied contamLD72 and a newly developed method that analyses contamination in ROH for female and male libraries (see Supplementary Information, section2 for a detailed description). Genome-wide patterns of selection in 230 ancient Eurasians. The analysed genomes also show that the descendants of these Epigravettian inhabitants of the Italian peninsula spread across the rest of Europe about 14,000 years ago, replacing populations associated with the Magdalenian culture. The f4-statistics were calculated by qpDstat 755 with parameter f4 mode: YES, with the Mbuti.DG population from Africa used as outgroup in all f-statistics analyses. PACEA co-authors of this research benefited from the scientific framework of the University of Bordeauxs IdEx Investments for the Future programme/GPR Human Past. - Developing a high . Get the latest science news in your RSS reader with ScienceDaily's hourly updated newsfeeds, covering hundreds of topics: Keep up to date with the latest news from ScienceDaily via social networks: Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. of Leiden, 2000). 26, 827833 (2016). https://doi.org/10.1038/s41586-023-05726-0, DOI: https://doi.org/10.1038/s41586-023-05726-0. Human bones and teeth were sampled in clean room facilities to minimize the inclusion of modern human DNA contamination during this procedure. The dates were calibrated using OxCal 4.452 with calibration curve IntCal20 at 95.4% probability53 and when multiple dates were available for the same individual we used the function R_Combine to combine them52. CONTACT US Contact us. For individual heterozygosity calculation, we also called pseudo-diploid genotypes from each library, using pileupCaller 1.4.0.3 under random diploid calling mode and the same strategy for different types of libraries as pseudo-haploid genotype calling. 2, e190 (2006). & Hlie, J. F. Temperature and precipitation regime in LGM human refugia of southwestern Europe inferred from 13C and 18O of large mammal remains. The hunter-gatherers were grouped based on their geographic origins and dates (Supplementary Information, section5). The research team describes a large-scale genetic replacement that may have been caused, in part, by climatic changes that forced people to migrate: "At that time, the climate warmed up quickly and considerably and forests spread across the European continent. The compiled genotype file used for analyses, including re-genotyped published genomes, has been uploaded at the Edmond Data Repository of the Max Planck Society (https://edmond.mpdl.mpg.de/dataset.xhtml?persistentId=doi:10.17617/3.Y1KJMF). In addition to her rich experience, including bioinformatics cancer research at OICR, Tina is a popular YouTuber with over 60K subscribers. Meet Tina Huang. Damgaard, P. et al. The observation that post-14ka individuals from western and central Europe andalso from Britain41 carry a homogeneous genetic makeup instead of displaying repeated local admixtures with GoyetQ2 ancestry implies that the Oberkassel-ancestry profile was already largely formed before its dispersal. Designed for aspiring data scientists, data analysts, and BI analysts, this course is the perfect resource for anyone who needs a winning strategy to pass the SQL interview and land their dream job. ADS Tina Huang - Wikipedia The horizontal dashed line marks the boundary between Late Pleistocene and Holocene. 9 posts. In the MDS plot, the Le Piage II individual falls particularly close to individuals belonging to the Fournol cluster, suggesting a local genetic continuity of this ancestry during the LGM (Supplementary Fig. Tina is a data scientist working in tech and does Youtube part time. Front. 27, 576582 (2017). In the meantime, to ensure continued support, we are displaying the site without styles 864358 (to K.M. The inferred pattern of short ROH (48 cM, visualized in blue) being common is in stark contrast to most later farmer populations, where the majority of individuals have no short ROH whatsoever (see101), and evidences small effective population sizes across West Eurasian hunter-gatherer groups. In particular, the 13ka Pradis 1 individual from northeastern Italy represents the most basal lineage compared to all other Epigravettian-associated individuals, including the older Tagliente 2 and Villabruna genomes from northern Italy (group 1). The human remains were processed in dedicated laboratories at the Max Planck Institute for the Science of Human History in Jena (Germany), University of Tbingen (Germany), University of Florence (Italy), Leiden University Medical Center (the Netherlands) and University of Tartu (Estonia). Where it all started :) I make weekly videos about self learning, practical productivity, and coding. Everything you need to know is included in the course. 4b and Supplementary Data 3.C). Palma di Cesnola, A. EY. The Kostenki (and Sunghir group) ancestry contributed to the previously described Vstonice cluster represented by Gravettian-associated individuals from central-eastern and southern Europe4. Metadata information of studied individuals. Paradis, E., Claude, J. Curr. PubMed Mittnik, A. et al. They were different in many aspects, including their skin and eye colour," says He Yu. At the same time, these two groups started mixing with each other, and continued to do so for around 3,000 years," Krause says. Proc. Long-term Outcomes in Critically Ill Patients With COVID-19 in the 2014-2020.4.01.16-0030) and C.L.S. By contrast, the Goyet Q116-1 genetic profile gave rise to the newly described Fournol cluster identified in Gravettian-associated individuals from western and southwestern Europe. Tina Huang. Genome Biol. In practice, we use machine learning in different conjunctures. First Name Tina. ISSN 0028-0836 (print). Individuals with at least one library showing Y/Auto ratio > 0.2 were determined as maleindividuals, and with Y/Auto < 0.2 were determined as femaleindividuals4 (Supplementary Fig. Her YouTube channel advises data science jobs, self-study, boosting productivity, resume reviews, etc. Protoc. The single-stranded library of Cuiry Les Chaudardes 1 was produced with partial UDG treatment (ss_halfUDG)62 (Supplementary Data 1.B). This research aims to determine whether a neural response telemetry (NRT) threshold determines the success of surgery. of estimates from 5-cM-block jackknife analysis. Highly recommended for not only people preparing for interviews but for people that just want to improve their coding skills. Google Scholar. My name is Tina and I'm a data scientist and YouTuber. Here, data really gets to shine, in that its both the source of truth and the driver of insights. Rohland, N. & Hofreiter, M. Ancient DNA extraction from bones and teeth. 1). @hellotinah. The Roger Rabbit's Trousers (1990 film) Credits | JH Movie Collection 10 and 11). Ontario Institute for Cancer Research Toronto, ON. The length of each coloured bar represents the fraction of individuals carrying the corresponding haplogroup (legend on the right of each panel). The course you are purchasing is still hosted by 365 Data Science and comes with most of the perks of our dedicated platform resume builder, user dashboard, Q&A hub, and more. Finally, we estimated the genetic diversity of Epigravettian-associated individuals in the dataset by calculating both pairwise mismatch rates (PMR) on pseudo-haploid genotypes and individual heterozygosity levels on pseudo-diploid genotypes (Supplementary Data 3.A). Provided by the Springer Nature SharedIt content-sharing initiative. Check out Why is Burnout So Common in Tech? The de-multiplexed capture sequencing reads were cleaned and mapped to human reference genome hs37d5 using EAGER pipeline 1.92.5564. When expanded it provides a list of search options that will switch the search inputs to match the current selection. Sep 2017 - Aug 20181 year. Tina Huang - Senior Tax Analyst - Lion | LinkedIn Tina Huang. 6 Easy Ways to Support (Boost) Your Immune System Naturally The grouping of Epigravettian-associated populations is shown with the same colour in a. It is generated automatically, and you can download, view, and share it at any time. 27, 18011810.e10 (2017). J. Anthropol. R. Soc. This is also supported by f4-statistics of the form f4(Mbuti, Fournol 85; Sunghir, test), which are significantly positive for all the individuals included in the Vstonice cluster (Supplementary Data 2.B). Individuals at this site might mark one of the last occurrences of such high levels of hunter-gatherer-related ancestries, just centuries before the emerging European Bronze Age. Contrary to the proposal in Fu et al.4 but in agreement with Petr et al.17, we do not observe a substantial decrease of Neanderthal ancestry in most European hunter-gatherers through time (Supplementary Information, section6 and Supplementary Figs. Hi! My name is Tina and I'm a data scientist and YouTuber. and T. Saupe received support from the European Union through the European Regional Development Fund (project no. Nat. Herein, methane is upgraded through the photocatalytic oxidative coupling of methane (OCM) over a ternary Ag-AgBr/TiO 2 catalyst in a pressurized flow reactor. This, together with the evidence of Villabruna ancestry in El Mirn 19ka, further suggests that this genetic discontinuity could be the result of palaeogeographic and palaeoecological transformations connected to the LGM32, rather than to the BllingAllerd warming period4,15 (14.712.9ka). She has been working for the data sciences industry since 2014. A draft sequence of the Neandertal genome. After 7.5ka, as ANF ancestry had reached regions north of the Alps, individuals carrying a hunter-gatherer genetic profile were primarily restricted to the northern fringes of Europe (Fig. Conversely, individuals in the Sidelkino cluster are genetically closer to AG3 than Tutkaul 1. This free online conference is featuring panel discussions from Tinas authentic and engaging delivery style allows her to create original content on topics like how to be more productive, how to learn more efficiently, how to land a job in data science, and more. Palaeogenomics of Upper Palaeolithic to Neolithic European hunter On the basis of the genetic variation of present-day Europeans, this could imply phenotypic differences between post-14ka hunter-gatherer populations across Europe, with individuals in the Oberkassel cluster possibly exhibiting darker skin and lighter eyes, and individuals in the Sidelkino cluster possibly lighter skin and darker eye colour. The formation of human populations in South and Central Asia. 724703 and no. The emergence of hunter-gatherer pottery in the Urals and West Siberia: new dating and stable isotope evidence. Schubert, M., Lindgreen, S. & Orlando, L. AdapterRemoval v2: rapid adapter trimming, identification, and read merging. Here we analyse 356 ancient hunter-gatherer genomes, including new genomic data for 116 individuals from 14 countries in western and central Eurasia, spanning between 35,000 and 5,000 years ago. Floor Coatings. Emergence of human-adapted Salmonella enterica is linked to the Neolithization process. Pleistocene North African genomes link Near Eastern and sub-Saharan African human populations. Thats it for today. Population genomics of Mesolithic Scandinavia: investigating early postglacial migration routes and high-latitude adaptation. However, one of my favorites is using supervised learning techniques, such as random forest, SVM, and XGBoost, to discover which features contribute the most to the success of a product. Google Scholar. We visualize the total amount of ROH longer than 4 cM for (a) pre-LGM individuals, (b) Epigravettian- and Magdalenian-associated individuals, (c) individuals carrying high proportions of Sidelkino-related ancestry, and (d) individuals carrying high proportions of Oberkassel-related ancestry. Article Tina Llorca CPA, CWP, CEPP, CIS, MDRT Expand search. Then we merged the genotypes from different libraries of the same individual, by randomly picking alleles from available genotype calls, using a custom script. Ancient genome-wide DNA from France highlights the complexity of interactions between Mesolithic hunter-gatherers and Neolithic farmers. The genetic history of Ice Age Europe. Therefore, the broader terms archaeological culture or simply culture are used here to refer to archaeologically defined material cultures without implying links to modern anthropological and/or ethnographical concepts of culture. Raghavan, M. et al. B. et al. 211 and Supplementary Table 1). 1999 - 20001 year. 255, 106796 (2021). Tina Huang. Find contact's direct phone number, email address, work history, and more. ADS We thus modelled individuals belonging to the GoyetQ2 cluster and El Mirn as a mixture between the Fournol 85 and Arene Candide 16 genomes as proxies to represent the Fournol and Villabruna ancestries, respectively, in Magdalenian-associated groups (Fig. About me. Fu, Q. et al. In product development, 80% of the success of a product is determined by 20% of its features. "Ice Age survivors." Maier, A. This website is about taking one step at a time to ultimately live more fulfilling lives. The genetic distinction between the Oberkassel and Sidelkino clusters is also clearly noticeable in the diversity of uniparentally inherited markers, as the Oberkassel cluster is dominated by mtDNA haplogroup U5 and Y-chromosome haplogroup I, whereas individuals from the Sidelkino cluster show a higher frequency of mtDNA haplogroups U2, U4 and R1b, and carry uniquely Y-chromosome haplogroups Q, R and J (Extended Data Figs. 71, 465492 (2015). Greater San Diego Area. Former Apple and Twitter Engineer Explains Why She Started - Insider 365 Data Use Cases: Data Science and Product Development with Tina Huang 5). Nat. Adv. Sign In Create Free Account. Libraries were quantified using the IS7 and IS8 primers59 in a quantification assay using a DyNAmo SYBR Green qPCR Kit (Thermo Fisher Scientific) on the LightCycler 480 (Roche). Previously worked at Goldman Sachs and the Ontario Institute for . get subscribed to the Brandwatch Bulletin. Weissensteiner, H. et al. 4 and Supplementary Data 3.C). Protoc. S.T. Taiwan. ), no. Publicacin de Tina Llorca CPA, CWP, CEPP, CIS, MDRT Article Quat. I'm a data scientist and youtuber. The 3 Greatest Moments in science library uga hours History, Addicted to hills science diet adult small bites? Contrary to West Siberian hunter-gatherers, Tutkaul 1 does not carry an extra eastern Eurasian ancestry, but shows affinity to Iranian Neolithic farmers and some younger populations from Iran and the Turan region (Supplementary Data 2.L). Notes 9, 88 (2016). I hold a Bachelors degree at the University of Toronto where I studied pharmacology. Third, Magdalenian-associated individuals not only from Iberia but also from the rest of Europe carry Epigravettian-associated ancestry (Villabruna cluster). Nat. While terms such as lithic industry, techno-complex, prehistoric tradition, and so on might be more appropriate to refer to the various associated chrono-cultural subdivisions, they concern different levels of discussion and are not applicable to all contexts investigated here. Learn with a sense of purpose. SQL for Tech and Data Science Interviews | Udemy